In isolated blood cells, hyperbaric oxygen therapy improves telomere length and lowers immunosenescence.

The treatment of increasing dissolved oxygen in human tissues by providing 100% pure oxygen in an environment higher than atmospheric pressure is known as hyperbaric oxygen therapy (HBOT). We know that there are two important markers of aging at the cellular level: telomere shortening and cell senescence. Telomeres are nucleotide repeats found at the ends of chromosomes that help to keep the genome stable. They shorten during mitosis and in the human body by roughly 20-40 bases per year. When telomeres reach a threshold length, cells begin to age or die.

Telomere length has been linked to a variety of disorders, with research indicating that short telomeres are connected with an increased risk of death. Cell senescence is a state of cell cycle stasis; senescent cells increase with aging, and their accumulation exacerbates senescence. Many medications and lifestyle interventions have been investigated to combat these two alterations, so what are the magic ways of hyperbaric oxygen therapy discussed today? This is about to bring up an intriguing hyperoxia-hypoxia conundrum.

Intermittent hyperoxia exposure can result in adaptive responses such as enhanced antioxidant-related gene expression and adaptation to increased reactive oxygen species by boosting antioxidants. Because antioxidants have a longer half-life than active oxygen, antioxidant activity continues to grow after returning to normal oxygen levels.Furthermore, intermittent hyperoxia exposure can induce many physiological responses during hypoxia, such as hypoxia inducible factor (HIF) release, as well as cell cascade responses such as angiogenesis, mitochondrial biogenesis, stem cell mobilization, and so on.

All of these things may aid in the fight against aging. A scientific team from Israel recently conducted the study at Aging. Participants were instructed to use a mask to receive pure oxygen at two atmospheres for 90 minutes at a time, with a five-minute break every 20 minutes. The treatment was given five times a week for three months, for a total of 60 times. The blood samples of the patients were collected for analysis after the 30th treatment, 60 treatments, and 1-2 weeks after all treatments were completed.

Clinical investigations revealed that when healthy older people were treated with hyperbaric oxygen for 60 minutes, their telomeres of peripheral blood mononuclear cells (PMBC) were dramatically lengthened by more than 20%, and their aging cells were reduced by up to 37%.
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